Ibuprofen: What NOT to Mix with This Common Painkiller (2025)

The NHS has issued a critical alert regarding the use of ibuprofen, a common over-the-counter pain reliever, emphasizing a specific combination that should never be mixed. This warning is not about alcohol, as one might assume, but rather a natural supplement that could lead to significant health issues when combined with ibuprofen. This revelation might surprise many, as ibuprofen is widely accessible and often used for various ailments.

Ibuprofen, available in most UK supermarkets and pharmacies, is a go-to solution for managing pain and inflammation. It works by reducing hormones that trigger aches and pains, offering relief for conditions like back pain, period pain, toothache, and symptoms associated with colds, flu, or COVID-19. Typically, individuals take three to four doses per day, in tablet, capsule, or granule form, mixed with water or liquid, with the duration of its effect depending on the milligrams per dose.

The NHS advises taking ibuprofen with a meal, snack, or milk to reduce stomach upset. However, it's crucial to note that ibuprofen may take longer to start working if taken just after food. For short-term pain, ibuprofen is usually taken for a day or two, but for long-term health conditions, it may be required for an extended period.

While ibuprofen is generally safe when combined with paracetamol or codeine, it's essential to avoid mixing it with other painkillers like aspirin or naproxen without consulting a pharmacist or doctor. These medications belong to the same family of non-steroidal anti-inflammatory drugs (NSAIDs), and taking them together can increase the risk of side effects, such as stomach discomfort.

The NHS also highlights the importance of maintaining normal eating and drinking habits while taking ibuprofen, with a specific caution regarding the supplement gingko biloba. It advises against taking gingko biloba with ibuprofen as it can increase the risk of bleeding. Additionally, due to limited testing, the safety of other herbal remedies and supplements when combined with ibuprofen is uncertain.

Furthermore, the article mentions that approximately one in 100 individuals may experience common side effects from ibuprofen, and in rare cases, severe allergic reactions (anaphylaxis) can occur. If any serious side effects are noticed, immediate medical attention is advised.

Ibuprofen: What NOT to Mix with This Common Painkiller (2025)
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